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Target intelligence / Profile preview
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5)
- Target
- PDE5
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5) is an enzyme that catalyzes the hydrolysis of cGMP to 5'-GMP. It plays a crucial role in regulating intracellular cGMP concentrations, modulating signal transduction pathways involved in smooth muscle relaxation and other physiological processes. PDE5 is a therapeutic target for erectile dysfunction and pulmonary hypertension, with inhibitors like sildenafil, tadalafil, and vardenafil used to increase cGMP levels and promote vasodilation.
- Other names
- GMP-PDE alphaRod/PDE V-B1
02
Mechanism of action
Selective inhibition of PDE5, increasing cGMP levels and promoting smooth muscle relaxation.
03
Biological functions
Regulation of smooth muscle contraction and relaxationRegulation of cGMP signalingHydrolysis of cGMP to 5'-GMP
04
Disease associations
Erectile dysfunctionPulmonary hypertensionCardiovascular diseaseCancer
05
Safety considerations
Potential for drug interactions with nitratesCardiovascular side effectsVisual disturbances
06
Interacting drugs
Sildenafil
3 more in the full profile.
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