Chemokine (C-C motif) ligand 24 (CCL24)

Chemokine (C-C motif) ligand 24 is a member of the CC chemokine family, distinguished by the presence of two adjacent cysteines. Primarily secreted by monocytes, macrophages, and bronchial epithelial cells, CCL24 exerts a strong chemotactic influence on eosinophils and, to a lesser degree, resting T lymphocytes and neutrophils. Its biological activity is closely linked to inflammatory and allergic disorders, where elevated levels are a hallmark of disease. CCL24 interacts with the chemokine receptor CCR3 to mediate immune cell recruitment in tissues. The molecule has demonstrated implications not only in the regulation of inflammation but also in disease modulation, such as diabetic nephropathy, by controlling tissue infiltration of immune cells and fibrosis. Research into CCL24 as a therapeutic target seeks to reduce pathological inflammation in severe allergic and chronic inflammatory conditions.

Other names

eotaxin-2MPIF-2myeloid progenitor inhibitory factor 2

Drugs or antibodies targeting CCL24 typically act by inhibiting its binding to CCR3 receptor, thereby reducing eosinophil and lymphocyte chemotaxis and subsequent inflammation