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Target intelligence / Profile preview
Chemokine (C-C motif) ligand 7 (CCL7)
- Target
- CCL7
- Molecular classification
- Chemokine, CC chemokine family, Cytokine
01
Overview
Chemokine (C-C motif) ligand 7 (CCL7), also known as monocyte-chemotactic protein 3 (MCP-3), is a small cytokine belonging to the CC chemokine family. It acts as a chemoattractant for monocytes/macrophages and other immune cells, playing a key role in inflammation, tissue injury, and cancer progression. CCL7 exerts its effects through binding to receptors such as CCR1, CCR2, CCR3, CCR5 and CCR10.
- Other names
- Monocyte-chemotactic protein 3MCP-3SCYA7
02
Mechanism of action
N/A
03
Biological functions
Chemoattraction of monocytes/macrophagesImmune cell recruitmentRegulation of inflammatory responsesRegulation of tumor invasion/metastasisModulation of mast cell functionRegulation of invadopodia maturationMatrix metalloproteinase-mediated collagen degradation
04
Disease associations
InflammationMetastasisCancerAllergic diseasesOcular hypersensitivity reactions
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