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Target intelligence / Profile preview
Chemokine (C-C motif) receptor 8 (CCR8)
- Target
- CCR8
- Molecular classification
- G protein-coupled receptor, Chemokine receptor, Class A GPCR
01
Overview
Chemokine (C-C motif) receptor 8 (CCR8) is a member of the beta chemokine receptor family and a class A G protein-coupled receptor (GPCR). It is preferentially expressed in thymus tissue, regulatory T cells (Tregs), and type 2 helper T cells (Th2). It plays a role in immune cell migration, monocyte chemotaxis, and thymic cell apoptosis. Its primary endogenous ligand is CCL1. In cancer contexts, it is upregulated on tumor-infiltrating Tregs, making it a target for cancer immunotherapy. Monoclonal antibodies targeting CCR8 are being developed to deplete intratumoral Tregs selectively.
- Other names
- CC-CKR-8CCR-8CDw198CKRL1CMKBR8CMKBRL2CY6GPRCY6TER1
02
Mechanism of action
Monoclonal antibodies targeting CCR8 deplete intratumoral Tregs, CCL1 and CCL8 act as agonists.
03
Biological functions
Mediates migration of immune cellsRegulates monocyte chemotaxisInfluences thymic cell apoptosisImmune regulationTreg suppressionDendritic cell migration
04
Disease associations
Multiple sclerosisStrokeRectal cancerMelanomaGastric cancerMetastatic brain cancerMetastatic liver cancerAutoimmune diseasesCancer
05
Safety considerations
Potential for broad immunosuppression if peripheral immunity is not spared by therapies.Modulating this pathway could lead to excessive immune activation in autoimmune diseases if not controlled.
06
Interacting drugs
CCL1
2 more in the full profile.
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