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Target intelligence / Profile preview
Chemokine (C-X-C motif) ligand 12 (CXCL12)
- Target
- CXCL12
- Molecular classification
- Chemokine, CXC chemokine family ligand
01
Overview
Chemokine CXCL12, also known as Stromal Cell-Derived Factor 1 (SDF-1), is a multifunctional chemokine with critical roles in development, immune regulation, and disease. It primarily signals through CXCR4 and CXCR7 receptors. The CXCL12/CXCR4 axis plays key roles in normal physiology such as maintenance of tissue stem cells, tissue repair/regeneration and cardio-protection. It is also implicated in disease associations such as cancer progression/metastasis/angiogenesis/survival, HIV infection, inflammatory diseases and coronary artery disease risk.
- Other names
- Stromal cell-derived factor 1SDF-1Pre-B-cell growth-stimulating factorPBSFSDF‑1α/CXCL12aSDF‑1β/CXCL12bSDF‑1γ/CXCL12g
02
Mechanism of action
Delivery of SDF‑1 for tissue repair/regeneration or inhibition/blockade for cancer/metastatic disease treatment.
03
Biological functions
ChemoattractantHematopoiesisCardiogenesisVascular formation/angiogenesisNeurogenesisImmune system regulationLymphopoiesisMyeloid progenitor cell survivalNeural progenitor patterningTissue stem cell maintenanceTissue repair/regenerationCardio-protection
04
Disease associations
Cancer progression/metastasis/angiogenesis/survivalHIV infectionInflammatory diseases (arthritis, pulmonary disorders)Coronary artery disease
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