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Target intelligence / Profile preview
Chemokine Receptor (CKR)
- Target
- CKR
- Molecular classification
- G protein-coupled receptor (GPCR)
01
Overview
Chemokine receptors are a family of G protein-coupled receptors (GPCRs) that bind chemokines and mediate leukocyte migration and immune cell trafficking. They play a crucial role in inflammation, immunity, and cancer. Modulation of chemokine receptor expression or function can enhance immune cell homing to tumor sites or inflamed tissues, improving the efficacy of adoptive cell therapy and cancer immunotherapy. Key mechanisms involve receptor internalization, recycling, and degradation, which can be targeted to fine-tune receptor availability at the cell surface.
- Other names
- Chemokine receptorsChemokine receptor family
02
Mechanism of action
Agonism, Antagonism, Modulation of receptor expression, Modulation of receptor internalization/recycling
03
Biological functions
Signal transductionLeukocyte migrationImmune cell traffickingInflammationCell signalingReceptor internalizationReceptor recyclingReceptor degradation
04
Disease associations
CancerInflammationAutoimmune diseasesChronic inflammationInfection
05
Safety considerations
Off-target effectsCytokine stormImmunosuppressionAltered immune homeostasis
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