Chemokine Receptor (CKR)

Chemokine Receptor Overview

Chemokine receptors are a family of G protein-coupled receptors (GPCRs) that bind chemokines and mediate leukocyte migration and immune cell trafficking. They play a crucial role in inflammation, immunity, and cancer. Modulation of chemokine receptor expression or function can enhance immune cell homing to tumor sites or inflamed tissues, improving the efficacy of adoptive cell therapy and cancer immunotherapy. Key mechanisms involve receptor internalization, recycling, and degradation, which can be targeted to fine-tune receptor availability at the cell surface.

Mechanism of Action

Agonism, Antagonism, Modulation of receptor expression, Modulation of receptor internalization/recycling

Biological Functions

Safety Considerations