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Target intelligence / Profile preview
Chloride Channel (Intestinal Epithelial Cell)
- Molecular classification
- Ion Channel
01
Overview
Chloride channels in intestinal epithelial cells are integral membrane proteins that mediate the transport of chloride ions across the apical and basolateral membranes of enterocytes. This process is essential for maintaining fluid balance, electrolyte homeostasis, and proper hydration of the intestinal mucosa. Key examples include CFTR, TMEM16A/ANO1 and ClC-2. They play critical roles in both normal physiological processes and disease states such as cystic fibrosis and secretory diarrhea.
02
Mechanism of action
Modulation of chloride ion transport across the intestinal epithelial cell membrane.
03
Biological functions
Chloride transportFluid balanceElectrolyte homeostasisMucosal hydration
04
Disease associations
Cystic fibrosisSecretory diarrhea
05
Safety considerations
Potential for electrolyte imbalanceOff-target effects on other ion channels
06
Interacting drugs
ARN23765
2 more in the full profile.
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