Cholecystokinin (CCK)

Cholecystokinin Overview

Cholecystokinin (CCK) is a peptide hormone that plays a crucial role in digestion and satiety. It is synthesized by enteroendocrine I cells in the small intestine and neurons in the enteric and central nervous systems. CCK stimulates pancreatic enzyme secretion, gallbladder contraction, and inhibits gastric emptying. It also acts as a satiety signal in the brain, modulating appetite and food intake. CCK exerts its effects through two main receptors: CCK1, primarily located in the gut and pancreas, and CCK2, predominantly found in the brain and stomach.

Mechanism of Action

CCK acts by binding to CCK1 and CCK2 receptors, which are G protein-coupled receptors. CCK1 activation primarily stimulates digestive processes, while CCK2 activation has roles in gastric acid secretion and anxiety modulation.

Biological Functions

Safety Considerations