Cholecystokinin A receptor (CCK1R) (CCK1R)

The Cholecystokinin A receptor (CCK1R) is a G protein-coupled receptor primarily located in the gastrointestinal tract and specific regions of the central nervous system (UniProt P32238). It plays a critical role in regulating digestive processes, including the stimulation of pancreatic enzyme secretion, gallbladder contraction, and the slowing of gastric emptying (IUPHAR/BPS Guide to Pharmacology). Beyond digestion, CCK1R is a key mediator of postprandial satiety, making it a significant target for obesity and metabolic disorder research (PubMed PMID: 25051059). In disease states, dysregulation of CCK1R signaling is associated with gallbladder dysfunction, irritable bowel syndrome, and certain types of cancer, particularly pancreatic adenocarcinoma (NCBI Gene ID: 886). Pharmacological modulation of the receptor includes agonists developed to induce weight loss and antagonists aimed at treating gastrointestinal motility disorders or pain (StatPearls: Physiology, Cholecystokinin). Despite its therapeutic potential, targeting CCK1R presents challenges such as maintaining selectivity over the closely related CCK2 receptor and managing gastrointestinal side effects.

Other names

CCK-A receptorCCKARCholecystokinin receptor type 1Cholecystokinin receptor type ACCK1 receptor

Agonism of the receptor stimulates satiety and digestive enzyme release, while antagonism is used to inhibit gastrointestinal motility and reduce pain (IUPHAR/BPS Guide to Pharmacology).