Gosset Cholesterol induced regulator of metabolism RNA Overview
Cholesterol induced regulator of metabolism RNA (CHROMR, also known as CHROME or PRKRA-AS1) is a primate-specific long non-coding RNA located on human chromosome 2q31.2. CHROMR is upregulated in plasma and arterial plaques of patients with cardiovascular disease, and its expression is regulated by sterol-activated LXR transcription factors. Functionally, CHROMR promotes cholesterol efflux and HDL synthesis by inhibiting the activity of specific microRNAs (miR-27b, miR-33a/b, miR-128) that otherwise suppress ABCA1, an essential gene for HDL formation. Knockdown of CHROMR reduces cholesterol efflux and impairs nascent HDL biogenesis. CHROMR is being explored as a biomarker and experimental regulator for cholesterol-related diseases but is not a direct drug target, nor is it a receptor, enzyme, or transporter.
Mechanism of Action
Biological Functions
Disease Associations
Safety Considerations
- Limited pharmacological tractability
- Therapeutic targeting challenges due to poor conservation across species
Associated Biomarkers
| Biomarker |
|---|
| Plasma CHROME/CHROMR levels (for cholesterol-related diseases, e.g. cardiovascular disease) |