Choroidal neovascular endothelium (CNV endothelium) (CNV endothelium)

Choroidal neovascular endothelium refers to the specialized layer of endothelial cells that form abnormal, leaky blood vessels originating from the choroid and extending into the subretinal space [1][6]. This pathological process, known as choroidal neovascularization (CNV), is the hallmark of neovascular age-related macular degeneration (nAMD) and is a leading cause of severe vision loss [1][10]. These endothelial cells are characterized by high sensitivity to pro-angiogenic factors, particularly vascular endothelial growth factor (VEGF), which drives their proliferation, migration, and increased vascular permeability [2][14]. Therapeutic strategies primarily focus on neutralizing VEGF or its receptors to inhibit vessel growth and reduce fluid leakage [1][17]. Additionally, photodynamic therapy (PDT) uses light-activated drugs like verteporfin to selectively damage these cells [9][10]. While not a single molecule, the CNV endothelium serves as a critical cellular target for a wide range of biologics and small molecules aimed at preserving retinal architecture and visual function [6][13].

Other names

CNV endothelial cellsNeovascular choroidal endotheliumPathological choroidal endotheliumChoroidal neovascular membrane endothelium

Inhibition of VEGF-A signaling, inhibition of Ang-2, and photoactivation-induced cytotoxicity [1][2][10].