Chromodomain-helicase-DNA-binding protein 7 (AeCHD7) (AeCHD7)

AeCHD7 is a chromatin-remodeling protein in the Aedes aegypti mosquito, belonging to the Chromodomain-helicase-DNA-binding (CHD) family and serving as the ortholog of the Drosophila Kismet protein. It contains conserved chromodomains, an SNF2-related helicase domain, and BRK domains, which allow it to regulate gene expression by modifying chromatin structure. Research has identified AeCHD7 as a critical pro-viral host factor for the Dengue virus (DENV); its expression is significantly upregulated during infection, and its presence is necessary for efficient viral replication. Experimental depletion of AeCHD7 via RNA interference has been shown to severely reduce DENV titers in mosquito tissues. Furthermore, AeCHD7 is a key target in Wolbachia-mediated pathogen blocking, as Wolbachia infection leads to the downregulation of AeCHD7, thereby contributing to the mosquito's resistance to viral pathogens. Given its central role in determining vector competence, AeCHD7 is considered a promising target for genetic or chemical interventions aimed at controlling the transmission of arboviruses like Dengue and Zika. However, therapeutic development must account for the high conservation of CHD7 in humans to avoid serious off-target effects, as human CHD7 mutations are linked to the developmental disorder CHARGE syndrome.

Other names

KismetAAEL002230CHD7Chromodomain-helicase-DNA-binding protein 7

Inhibition of viral replication through the depletion or downregulation of essential pro-viral host factors required for the viral life cycle.