Chromosome 22 open reading frame 46, pseudogene (C22orf46P)

C22orf46P (chromosome 22 open reading frame 46, pseudogene) is annotated as a pseudogene in the human genome and therefore does *not* encode a functional protein product under standard genomic annotation conventions[1][4][7]. However, there is some ambiguity and potential confusion in the literature. The parent gene name "C22orf46" (sometimes also referred to as FLJ23584 or CTA-216E10.6) has been suggested by recent studies to actually encode a nuclear/nucleolar protein, called Tumor Apoptosis Associated Protein 1 (TAAP1), with roles in anti-apoptotic signaling in some cancer models[2]. This newly suggested function is for C22orf46/FLJ23584, not explicitly the pseudogene C22orf46P, which is officially annotated as a non-functional genomic element. For C22orf46P (the pseudogene, with 'P'), there is **no evidence of a therapeutic target role or interaction with drugs, nor any validated biological or disease function**[1][4][7]. There are no reported biomarkers, mechanisms of action, or safety concerns. The use of this symbol as a target is incorrect—C22orf46P itself is not considered a protein-coding target in drug discovery or therapeutics. The confusion stems from closely related names in the literature: **C22orf46** (without 'P'), whose product (FLJ23584/TAAP1) may have actual biological relevance in cancer and apoptosis[2]. Therefore, if your intent is a therapeutic target, be aware: - **C22orf46P** is a pseudogene and not a target. - **C22orf46 (TAAP1/FLJ23584)**, not the pseudogene, may encode a functional anti-apoptotic protein, but this is an emerging area and not yet standard nomenclature. If you require structured information for a therapeutic or biomarker role, you should refer to “C22orf46” (without 'P') or “Tumor Apoptosis Associated Protein 1” (TAAP1) instead[2]. **Summary:** C22orf46P is a pseudogene, not a therapeutic target; using it as a drug target is incorrect. If you are seeking biologically meaningful target information, reference C22orf46 (TAAP1) instead[1][2][4][7].

Other names

C22orf46FLJ23584CTA-216E10.6ENSG00000184208