Target intelligence / Profile preview

Chymotrypsin

Molecular classification: Enzyme, Protease, Serine Protease, Serine endopeptidase

Overview

Chymotrypsin is a serine protease enzyme primarily involved in the digestion of proteins in the small intestine. It catalyzes the hydrolysis of peptide bonds, specifically those adjacent to aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. It is synthesized in the pancreas as an inactive precursor (chymotrypsinogen) and activated in the digestive tract.

Mechanism of action

Covalent hydrolysis of peptide bonds adjacent to aromatic amino acids (Phe, Trp, Tyr) via acyl-enzyme intermediate formation.

Biological functions

ProteolysisProtein digestion

Disease associations

Malabsorption (indirectly)Pancreatic insufficiency (indirectly)Cystic fibrosis (indirectly)

Safety considerations

Potential for off-target proteolysisAutolysis and instability under certain conditionsInhibition by heavy metals

Interacting drugs

Protease inhibitors (general)

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