Citric Acid Cycle Enzyme System (TCA Cycle)

Citric Acid Cycle Enzyme System Overview

The citric acid cycle enzyme system, also known as the Krebs cycle or tricarboxylic acid (TCA) cycle, is a series of enzyme-catalyzed biochemical reactions that occur in the mitochondrial matrix of eukaryotic cells. This system is central to cellular metabolism, serving as the final common pathway for the oxidative catabolism of carbohydrates, fatty acids, and amino acids. The primary function is to oxidize acetyl-CoA to carbon dioxide (CO₂), while reducing coenzymes NAD⁺ and FAD to NADH and FADH₂. These reduced coenzymes then feed electrons into the electron transport chain for ATP production. Intermediates serve as precursors for biosynthesis of amino acids, nucleotides, heme groups, etc. Defects or deficiencies in any component enzyme can lead to metabolic disorders with wide-ranging effects due to impaired energy production.

Mechanism of Action

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Biological Functions

Safety Considerations