Citric Acid Cycle Enzymes (TCA Enzymes)

The citric acid cycle (also known as the Krebs cycle or tricarboxylic acid [TCA] cycle) is a central metabolic pathway that takes place in the mitochondrial matrix of eukaryotic cells. It is responsible for the oxidative catabolism of carbohydrates, fats, and proteins, converting acetyl-CoA into carbon dioxide while generating high-energy electron carriers (NADH and FADH2) and GTP/ATP. The enzymes catalyzing this cycle are essential for cellular respiration and energy production. The main enzymes involved are: Citrate synthase, Aconitase, Isocitrate dehydrogenase, α-Ketoglutarate dehydrogenase complex, Succinyl-CoA synthetase, Succinate dehydrogenase, Fumarase, and Malate dehydrogenase. Defects in these enzymes can lead to metabolic disorders affecting energy production. Some intermediates/enzyme activities are also targets for certain drugs or toxins.

Other names

Krebs Cycle EnzymesTricarboxylic Acid Cycle Enzymes

Enzyme Inhibition