Molecular Classification
Claudin family protein, Transmembrane protein, Tight junction protein
Other Names
CLDN18 isoform 2
Disease Roles
Cancer

Claudin 18.2 Overview

Claudin 18.2 is a stomach-restricted tight junction protein that is aberrantly expressed on the surface of certain gastrointestinal tumors, making it a promising therapeutic target for antibody-based therapies and CAR-T cell therapy.

Mechanism of Action

Monoclonal antibody targeting CLDN18.2

Biological Functions

Tight junction formation
Paracellular barrier maintenance
Regulation of ion transport
Regulation of solute permeability

Disease Associations

Cancer

Safety Considerations

  • Potential for off-target effects in tissues with low CLDN18.2 expression
  • Immune-related adverse events

Interacting Drugs

Zolbetuximab

Associated Biomarkers

Biomarker
CLDN18.2 expression on tumor cells