Claudin-4 messenger RNA (CLDN4 mRNA) (CLDN4 mRNA)

Claudin-4 (CLDN4) messenger RNA is the transcript responsible for encoding the Claudin-4 protein, a key component of tight junction complexes that regulate paracellular permeability and maintain epithelial cell polarity [1, 2]. In various epithelial malignancies, including pancreatic, ovarian, and gastric cancers, CLDN4 mRNA is frequently overexpressed, contributing to tumor progression, cell survival, and chemoresistance [3, 4]. As a therapeutic target, CLDN4 mRNA is approached using RNA-based technologies such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs) to silence gene expression and reduce protein levels [5, 6]. This strategy aims to disrupt the tight junction barriers in tumors, potentially enhancing drug delivery and inhibiting metastatic pathways [7]. While protein-targeting agents like monoclonal antibodies are more clinically advanced, mRNA-targeted strategies offer high specificity for the CLDN4 sequence [8]. However, therapeutic development faces challenges such as the need for effective delivery systems to reach solid tumors and the risk of affecting normal epithelial tissues in the kidney and gut where Claudin-4 is physiologically active [9]. Monitoring CLDN4 mRNA levels through techniques like RT-qPCR or in situ hybridization serves as a critical biomarker for patient selection and assessing therapeutic efficacy [10]. Sources: [1] UniProt (P57730) [2] NCBI Gene (ID: 1364) [3] Michl et al. (2003), Gastroenterology (PMID: 12612053) [4] Honda et al. (2011), BMC Cancer (PMID: 21859467) [5] Kolomeyer et al. (2011), Exp Mol Pathol (PMID: 21475209) [6] Tsutsumi et al. (2015), J Control Release (PMID: 25893295) [7] Hewitt et al. (2006), BMC Cancer (PMID: 17460775) [8] Shiozaki et al. (2018), Cancer Sci (PMID: 30333295) [9] Morin (2012), Cancer Res (PMID: 22431867) [10] Lu et al. (2013), World J Gastroenterol (PMID: 23946593)

Other names

CPE-receptor mRNAWVP1 mRNACPETR1 mRNAClostridium perfringens enterotoxin receptor 1 mRNAClaudin-4 transcript

RNA interference (RNAi) mediated degradation of mRNA and antisense-mediated inhibition of translation, leading to the downregulation of Claudin-4 protein expression.