Clostridioides difficile (non-toxigenic strain) (Non-toxigenic C. difficile)

Clostridioides difficile is a Gram-positive, anaerobic, spore-forming bacterium that can colonize the human gut. Non-toxigenic strains lack the genes encoding toxins A and B (tcdA/tcdB) and binary toxin (cdtAB), and do not cause disease. They are being investigated as potential therapeutic agents for preventing or inhibiting colonization by toxigenic strains through competitive exclusion and other mechanisms such as nutrient competition, bile acid modification, and production of inhibitory metabolites. They are being developed as live biotherapeutics to restore microbial balance and prevent recurrent CDI.

Other names

Non-toxigenic C. difficileNon-toxigenic Clostridium difficiletcdA-/tcdB- C. difficilecdtAB- C. difficile

Competitive exclusion; nutrient competition; modification of bile acids to inhibit C. difficile spore germination and growth; production of inhibitory metabolites; inhibition of adhesion to intestinal epithelial cells.