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Target intelligence / Profile preview
Clostridium tetani Toxin (Tetanospasmin)
- Target
- Tetanospasmin
- Molecular classification
- Neurotoxin, Enzyme, Zinc endopeptidase
01
Overview
Clostridium tetani toxin, also known as tetanus toxin or tetanospasmin, is a potent neurotoxin produced by the bacterium Clostridium tetani. It inhibits neurotransmitter release, specifically glycine and GABA, leading to unopposed muscle contraction and spasms. It functions as a zinc-dependent endopeptidase that cleaves synaptobrevin-2. Tetanus results from wound contamination with C. tetani spores; these spores germinate and produce toxins that disseminate via blood or lymphatics.
- Other names
- Tetanus toxinTentoxylysin
02
Mechanism of action
Zinc-dependent endopeptidase that cleaves synaptobrevin-2, blocking the release of inhibitory neurotransmitters glycine and GABA.
03
Biological functions
Inhibition of neurotransmitter releaseCleavage of SNARE proteinsNeurotransmission disruption
04
Disease associations
TetanusInfection
05
Safety considerations
High potencySevere muscle spasmsRespiratory failureToxicity
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