Gosset Molecular Classification
Receptor, Protein complex, T cell co-receptor, Immunoglobulin superfamily
Other Names
T cell surface glycoprotein CD3
Disease Roles
Cluster of Differentiation 3 Overview
CD3 is a multimeric protein complex and T cell co-receptor that is essential for transmitting activation signals from the T cell receptor (TCR) upon antigen recognition. It is composed of epsilon (ε), gamma (γ), delta (δ), and zeta (ζ) chains, which assemble into heterodimers and homodimers. CD3 is ubiquitously expressed on all mature T lymphocytes and serves as a defining marker for cells committed to the T lineage. Anti-CD3 antibodies have been developed for research and clinical interventions to modulate immune responses.
Mechanism of Action
Modulating immune responses by targeting T cells
Biological Functions
T cell activation
Signal transduction
T cell development
Immune response
Disease Associations
Autoimmune diseases
Transplantation rejection
Lymphoma
Safety Considerations
- Immune suppression
- Cytokine release syndrome
Interacting Drugs
Anti-CD3 antibodies
Associated Biomarkers
| Biomarker |
|---|
| Pan-T-cell marker for identifying T cells in blood or tissue samples |