Coagulation factor II (Cynomolgus monkey) (F2)

Coagulation factor II, commonly known as thrombin in its active form, is a pivotal serine protease in the blood coagulation cascade. In Cynomolgus monkeys (Macaca fascicularis), this enzyme is highly homologous to human thrombin, which facilitates its use as a primary model in preclinical drug development for cardiovascular therapies [1][2]. Thrombin is responsible for converting soluble fibrinogen into insoluble fibrin, the structural scaffold of blood clots, and it also serves as a potent activator of platelets through protease-activated receptors (PARs) [3]. Beyond its procoagulant roles, it participates in inflammatory responses and wound healing [4]. Because of its central role in thrombosis, thrombin is a major therapeutic target for anticoagulants used to treat and prevent conditions like deep vein thrombosis, pulmonary embolism, and stroke [5]. Drugs targeting this molecule include direct thrombin inhibitors, which bind the enzyme's active site, and indirect inhibitors like heparin that work through antithrombin [6]. The high degree of conservation between the Cynomolgus and human versions of the protein ensures that binding affinities and inhibitory constants are often comparable across these species [2]. Monitoring thrombin activity is essential for managing bleeding risks associated with these therapies [4].

Other names

ThrombinProthrombinCoagulation factor IIaFIIaActivated factor II

Direct inhibition of the thrombin active site or indirect inhibition via antithrombin III to prevent fibrinogen conversion and platelet activation.