Coagulation Factor IIa (F2a)

Coagulation factor IIa, also known as thrombin, is the active form of prothrombin (coagulation factor II). It is a serine protease that plays a central role in blood coagulation by converting soluble fibrinogen into insoluble fibrin strands, forming the structural basis of a blood clot. Thrombin activates other coagulation factors, platelets, and has roles in cell proliferation, tissue repair, and angiogenesis. Dysregulation of thrombin activity can lead to thrombosis or bleeding disorders.

Other names

ThrombinFactor IIa

Serine protease that cleaves Arg-Gly bonds within target proteins, such as fibrinogen, to activate them. Inhibitors can bind to the active site, preventing substrate binding and thus its enzymatic function.