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Target intelligence / Profile preview
Coagulation Factor IX (FIX)
- Target
- FIX
- Molecular classification
- Serine protease zymogen, Peptidase family S1, Vitamin K-dependent protein
01
Overview
Coagulation Factor IX (FIX), also known as Christmas factor, is a vitamin K-dependent serine protease zymogen essential for normal hemostasis and blood clot formation. It is activated to Factor IXa by Factor XIa or VIIa/tissue factor, which then forms a complex with Factor VIIIa to activate Factor X. Deficiency or dysfunction leads to hemophilia B, treated with replacement therapy using plasma-derived or recombinant FIX.
- Other names
- Christmas factorF9HEMBP19PTCTHPH8Blood coagulation factor IXPlasma thromboplastin component
02
Mechanism of action
Replaces deficient or non-functional Factor IX to restore normal blood clotting ability.
03
Biological functions
Blood coagulationHemostasisActivation of Factor X
04
Disease associations
Hemophilia BBleeding disorder
05
Safety considerations
Thromboembolic eventsHypersensitivity reactionsDevelopment of inhibitors (antibodies against Factor IX)Anaphylaxis
06
Interacting drugs
Benefix®
4 more in the full profile.
07
Biomarkers
Factor IX activity levelsFactor IX antigen levels
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