Molecular Classification
Serine Protease Zymogen, Enzyme, Vitamin K-dependent protein
Other Names
Christmas Factor, Plasma Thromboplastin Component, PTC, F9, HEMB, P19, THPH8
Disease Roles
Hemophilia B

Coagulation Factor IX Overview

Coagulation factor IX, also known as Christmas factor, is a vitamin K-dependent plasma glycoprotein and a serine protease zymogen essential for normal blood coagulation. It is activated as part of the coagulation cascade and participates in both intrinsic and extrinsic pathways. Deficiency leads to hemophilia B.

Mechanism of Action

Replacement therapy; provides functional FIX to restore blood clotting ability.

Biological Functions

Hemostasis
Blood coagulation
Activation of Factor X

Disease Associations

Hemophilia B

Safety Considerations

  • Thrombotic complications
  • Development of inhibitors (antibodies against FIX)
  • Anaphylaxis

Interacting Drugs

Recombinant human FIX

Associated Biomarkers

Biomarker
Factor IX activity levels
F9 gene mutations