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Target intelligence / Profile preview
Coagulation Factor VIII (FVIII)
- Target
- FVIII
- Molecular classification
- Coagulation protein, Glycoprotein, Cofactor
01
Overview
Coagulation factor VIII (FVIII) is an essential blood clotting protein acting as a cofactor for activated factor IX (FIXa) in the activation of factor X. Deficiency or mutations in FVIII cause hemophilia A, a bleeding disorder. FVIII circulates bound to von Willebrand factor (vWF) and is activated by thrombin. Therapeutic innovations include recombinant FVIII products, gene therapy, and bispecific antibodies.
- Other names
- Antihemophilic factorAHFHEMA
02
Mechanism of action
Cofactor for FIXa-mediated activation of FX in the coagulation cascade, leading to thrombin generation and fibrin clot formation
03
Biological functions
Blood coagulationHemostasisActivation of Factor X
04
Disease associations
Hemophilia Avon Willebrand disease
05
Safety considerations
Inhibitor development (antibodies against FVIII)Thrombosis risk with excessive FVIII replacementImmune reactions to FVIII products
06
Interacting drugs
Recombinant FVIII
2 more in the full profile.
07
Biomarkers
FVIII plasma levelsFVIII activity
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