coagulation factor XIa, coagulation factor XIIa, plasma kallikrein

The provided input 'coagulation factor XIa, coagulation factor XIIa, plasma kallikrein' combines three distinct, though related, serine proteases. Coagulation factor XIa, coagulation factor XIIa, and plasma kallikrein are individual components of the contact system that play roles in blood coagulation, inflammation, and kinin generation. For proper structured data extraction, each should be handled as a separate canonical target, as each has unique characteristics, drug interactions, and disease associations despite their functional interplay.

This entry refers to multiple distinct serine proteases involved in the contact system. Drugs targeting these act via inhibition of their respective activities to modulate coagulation, kinin generation, and inflammation. For accurate structured data, each protein should be handled as an individual target.