Coagulation Factor XIIa (FXIIa)

Coagulation factor XIIa (FXIIa), also known as activated Hageman factor, is a serine protease enzyme that plays a central role in the initiation of the intrinsic pathway of blood coagulation and links coagulation with inflammation. It is generated from its zymogen precursor, coagulation factor XII (FXII), upon activation by contact with negatively charged surfaces. FXIIa initiates the intrinsic pathway of blood coagulation by activating factor XI to XIa and converting prekallikrein to kallikrein. Inhibiting FXIIa can reduce thrombosis risk without increasing bleeding tendency.

Other names

Activated Hageman factorHageman factorBeta-factor XIIA

Inhibition of FXIIa prevents activation of the intrinsic coagulation pathway and reduces thrombin generation without significantly affecting hemostasis, thus reducing thrombosis risk.