Coagulation Factors (excluding Fibrinogen, FVIII, vWF, FXIII) (Coagulation Factors (excl. I, VIII, vWF, XIII))

This entry represents a group of coagulation factors essential for blood clotting, excluding Fibrinogen (Factor I), Factor VIII, von Willebrand factor (vWF), and Factor XIII. These factors—II (prothrombin), V, VII, IX, X, XI, and XII—participate in the coagulation cascade, a series of enzymatic reactions leading to the formation of a stable blood clot. Deficiencies in these factors can lead to bleeding disorders, while their overactivation can contribute to thrombotic events. Many of these factors are serine proteases that activate downstream components in the cascade. Vitamin K is required for post-translational modification of Factors II, VII, IX, and X.

Other names

Prothrombin groupVitamin K-dependent clotting factors (II, VII, IX, X)Contact factors (XII, XI)Factors II, V, VII, IX, X, XI, XII

Various: Vitamin K antagonists inhibit post-translational modification of Factors II, VII, IX, and X. Heparin activates antithrombin, which inhibits several coagulation factors. DOACs directly inhibit specific factors like Factor Xa or Thrombin (Factor IIa).