Coagulation factors V, VIII, XI, XIII and related coagulation pathway components (Blood coagulation factors)

The coagulation factors V, VIII, XI, and XIII are essential proteins within the blood coagulation cascade, a physiological process designed to maintain vascular integrity through the formation of stable fibrin clots (StatPearls, NBK482256). Factor V (UniProt P12259) and Factor VIII (UniProt P00451) function as critical non-enzymatic cofactors that amplify the production of thrombin, the central enzyme of coagulation. Factor XI (UniProt P03951) is a zymogen of a serine protease that initiates the intrinsic pathway amplification, while Factor XIII (UniProt P00488) is a transglutaminase that stabilizes the final clot by cross-linking fibrin strands. Deficiencies in these factors lead to significant bleeding disorders, such as Hemophilia A (Factor VIII deficiency) and Hemophilia C (Factor XI deficiency), whereas their dysregulation can lead to life-threatening thrombosis (PubMed, 24762460). Pharmacological management involves the use of replacement factors or mimetics like emicizumab (DrugBank DB13924) to treat deficiencies, and the development of targeted inhibitors, particularly against Factor XI like abelacimab (DrugBank DB15883), to provide anticoagulation with a minimized risk of bleeding (PubMed, 33070335).

Other names

Blood clotting factorsCoagulation cascade componentsHemostatic factorsPlasma coagulation factors

Replacement of deficient proteins to restore hemostasis; mimetic activity to bypass missing cofactors; and inhibition of serine protease activity to prevent pathological thrombus formation (StatPearls, NBK482256; PubMed, 33070335).