Coagulation factors V, VIII, XIII and related substrates (F5, F8, F13)

This target entry represents a grouping of essential proteins in the blood coagulation cascade, specifically Factor V, Factor VIII, and Factor XIII. Factor V and Factor VIII serve as critical non-enzymatic cofactors that, when activated, dramatically accelerate the conversion of prothrombin to thrombin and Factor X to Factor Xa, respectively (Source: StatPearls, Coagulation Cascade). Factor XIII is a proenzyme transglutaminase that, once activated by thrombin, stabilizes the blood clot by cross-linking fibrin strands (Source: NIH, Factor XIII deficiency). These factors are primary therapeutic targets in the treatment of bleeding disorders such as Hemophilia A (Factor VIII deficiency) and various rare factor deficiencies. Conversely, their regulation is a focus in managing thrombotic risks, as Factor V Leiden mutations lead to resistance against inactivation, increasing the risk of venous thromboembolism (Source: Mayo Clinic). This entry is considered 'incorrect' as a single target because it aggregates multiple distinct proteins with different molecular functions and genetic origins into one substrate-based category.

Other names

Blood coagulation factorsProcoagulant cofactors and transglutaminasesFactor VFactor VIIIFactor XIII

Replacement therapy for deficient factors to restore hemostasis; mimetic antibodies to bypass missing cofactors; enzymatic cross-linking of fibrin to stabilize clots.