Coccidian parasite Overview
Coccidian parasite refers to a broad group of microscopic, spore-forming, single-celled protozoan parasites that belong to the subclass Coccidia within the apicomplexan class Conoidasida. These obligate intracellular parasites infect the intestinal tracts of vertebrates and invertebrates, causing coccidiosis, a disease characterized by diarrhea, weight loss, and sometimes severe illness or death. Genera within Coccidia include Eimeria, Isospora, Toxoplasma, Sarcocystis, and Neospora, among others. Anticoccidial therapy targets various vital parasite proteins or enzymes, but "coccidian parasite" is not a single molecular target or receptor; instead, it is a broad taxonomic and pathological group[1][4][7][8]. Key clarification: - The entry "Coccidian parasite" is not a molecular target (e.g., receptor, enzyme, transporter). It is a collective organismal classification. Therefore, entries like canonical_abbreviation, biomarkers, and precise mechanism details are either not applicable or are variable between the many species and genera within Coccidia. - If a molecular therapeutic target within coccidia (e.g., a specific protein kinase, transporter, or enzyme) is of interest, a more specific query should be made (e.g., "Coccidian calcium-dependent protein kinase 1") for the structured data you described[5][6][9].
Mechanism of Action
Amprolium: thiamine antagonist, prevents parasite replication Decoquinate: inhibits mitochondrial electron transport Diclazuril, toltrazuril, ponazuril: alter parasite organelles and/or inhibit nuclear division[2][8] Ionophores: disrupt cation balance in parasite cells[8]
Biological Functions
Disease Associations
Safety Considerations
- Development of drug resistance
- adverse effects on host microbiota
- potential toxicity with some treatments