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Target intelligence / Profile preview
Collagen (cleaved form)
- Molecular classification
- Other (structural protein fragment)
01
Overview
Cleaved collagen refers to collagen molecules that have been enzymatically digested—primarily by matrix metalloproteinases such as MMP-1—resulting in peptide fragments. Collagen is the main structural protein in the extracellular matrix of connective tissues, and its degradation is necessary for normal development, tissue repair, and pathological processes including cancer invasion and fibrosis[1][3][4][5]. Cleaved collagen fragments serve as biomarkers for connective tissue breakdown and are implicated in numerous disease states, but they do not constitute a unique drug target or receptor[3][5].
- Other names
- Cleaved collagen fragmentsCollagen degradation productsCollagen peptides (after enzymatic cleavage)
02
Biological functions
Structural role (reduced upon cleavage)Indicative of extracellular matrix remodelingBiomarker for tissue degradation
03
Disease associations
Cancer (tumor invasion and metastasis involves collagen cleavage)Inflammation (inflammatory tissue remodeling involves collagen breakdown)Other (fibrosis, arthritis, wound healing)
04
Biomarkers
Collagen cleavage fragments are used as biomarkers for tissue degradation, fibrosis progression, and response to therapy in several diseases
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