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Target intelligence / Profile preview
Collagen alpha-1(II) chain (COL2A1)
- Target
- COL2A1
- Molecular classification
- Collagen, Extracellular Matrix Protein
01
Overview
Collagen alpha-1(II) chain is a major component of type II collagen, a fibrillar collagen primarily found in cartilage and the vitreous humor of the eye. It provides structural integrity and tensile strength to connective tissues, essential for skeletal development, joint function, and tissue resilience. Mutations in COL2A1 are associated with various skeletal dysplasias and osteoarthritis, making it a relevant therapeutic target for these conditions.
- Other names
- Alpha-1 type II collagen
02
Mechanism of action
N/A
03
Biological functions
Structural supportCartilage formationEndochondral ossificationCell adhesionExtracellular matrix organization
04
Disease associations
Achondrogenesis type 2/hypochondrogenesisSpondyloepiphyseal dysplasia congenitaStrudwick typeLanger-Saldino achondrogenesisKniest dysplasiaStickler syndrome type IEarly-onset familial osteoarthritisChondrodysplasia
05
Safety considerations
Potential for off-target effects in collagen-related therapies.Development of neutralizing antibodies against collagen-based therapies.
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