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Target intelligence / Profile preview
Collagen beta(1-O)galactosyltransferase 1 (COLGALT1)
- Target
- COLGALT1
- Molecular classification
- Enzyme, Glycosyltransferase
01
Overview
Collagen beta(1-O)galactosyltransferase 1 (COLGALT1) is an enzyme that transfers beta-galactose to hydroxylysine residues in collagen, facilitating the formation of the collagen triple helix structure. It plays a crucial role in extracellular matrix organization and collagen stability. Dysfunctions in COLGALT1 have been associated with various collagen-related disorders, including brain small vessel disease and familial porencephaly. The enzyme acts within the endoplasmic reticulum and is involved in the biosynthesis of collagen types I and IV. COLGALT1 forms part of the procollagen lysine hydroxylation and glycosylation complex (KOGG complex) with other enzymes like LH3, contributing to the proper assembly and maturation of collagens.
- Other names
- Procollagen galactosyltransferase 1GLT25D1ColGalT 1FLJ22329Glycosyltransferase 25 family member 1Hydroxylysine galactosyltransferase 1BSVD3
02
Biological functions
Collagen glycosylationCollagen triple helix formationExtracellular matrix organization
03
Disease associations
Brain Small Vessel DiseaseFamilial PorencephalyCollagen-related disorders
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