Collagen type I (primary), with significant contributions from Collagen type V and smaller amounts of Collagen type III in the corneal stroma (COL1A1 (for collagen type I), COL5A1 (for collagen type V))

Collagen in the corneal stroma is a network primarily of type I collagen fibrils (with significant contribution from type V and smaller amounts of type III), tightly organized into superimposed lamellae to maintain corneal transparency, shape, and biomechanical strength[1][2][3][5]. Collagen V regulates the diameter and packing of collagen I fibrils, which is essential for transparency and tissue integrity[1][5]. The fibrils are associated with proteoglycans to support spacing, hydration, and physiological function[1][3][4]. Pathological changes in collagen content, structure, or organization underlie many corneal diseases, particularly thinning, scarring, and loss of transparency[1][5]. It is not a traditional receptor or enzymatic target, but is central to regenerative strategies and ocular surface disease management.

Other names

Corneal collagencorneal stromal collagenstromal collagens (often: collagen type I, collagen type V)

Collagen cross-linking (strengthening fibrils via photochemical reaction); Modulation of collagen degradation by inhibitors of enzymes (e.g., MMPs); Delivery of exogenous collagen or ECM scaffolds for repair