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Target intelligence / Profile preview
Collectrin, amino acid transport regulator (CLTRN)
- Target
- CLTRN
- Molecular classification
- Transporter, Metabolic protein, Type 1 transmembrane protein
01
Overview
Collectrin, amino acid transport regulator (CLTRN), is a type 1 transmembrane protein that plays an essential role in the trafficking and regulation of neutral amino acid transporters on the apical membrane of renal proximal tubule cells, notably SLC6A18 and SLC6A19, as well as possible additional transporters. It facilitates amino acid reabsorption and may also regulate SNARE complex formation in pancreatic beta cells, influencing insulin secretion and beta cell replication. CLTRN is highly expressed in the kidney and pancreas and is implicated in rare disorders of amino acid transport (such as Hartnup disorder) and neuropsychiatric phenotypes when mutated[2][3][5][6].
- Other names
- CollectrinCLTRNTMEM27Transmembrane protein 27NX17UNQ679/PRO1312kidney-specific membrane proteinNX-17collectrinNX17[2][6]
02
Mechanism of action
null (No approved drugs directly targeting collectrin as of current knowledge)
03
Biological functions
Amino acid transport regulationTrafficking amino acid transporters (notably SLC6A18, SLC6A19, SLC3A1, SLC7A9) to the cell surfaceRegulation of SNARE complex formationStimulation of pancreatic beta cell replicationInsulin secretion control in pancreatic beta cells
04
Disease associations
Hartnup disorderIminoglycinuriaNeuropsychiatric disorder (recessive, loss-of-function)
05
Safety considerations
Therapeutic targeting may pose risks of amino acid transport disruption, renal tubular dysfunction, or metabolic effects in pancreatic beta cells (inferred from biological function)
06
Biomarkers
Collectrin protein or mRNA expression (potential marker for renal tubular or pancreatic beta cell function)
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