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Colloid Osmotic Pressure via Glucose Polymers (Icodextrin) (COP via Icodextrin)
- Target
- COP via Icodextrin
- Molecular classification
- Polysaccharide, Synthetic Polymer, Osmotic Agent
01
Overview
Colloid osmotic pressure, generated by glucose polymers like icodextrin, is a crucial factor in fluid balance and waste removal, especially in peritoneal dialysis. Icodextrin's high molecular weight ensures sustained oncotic pressure in the peritoneal cavity, facilitating ultrafiltration. While effective, its use requires careful consideration of potential adverse effects and contraindications.
- Other names
- IcodextrinGlucose PolymersOncotic PressureExtraneal
02
Mechanism of action
Creates a sustained colloid/oncotic gradient to draw fluid and solutes from the blood into the peritoneal cavity via osmosis, facilitating ultrafiltration.
03
Biological functions
OsmosisFluid RetentionUltrafiltration
04
Disease associations
Kidney FailureFluid Overload
05
Safety considerations
HypertensionSkin rashCornstarch allergyMaltose/isomaltose intoleranceGlycogen storage diseasesLactic acidosisRisk of infection related to peritoneal dialysis
06
Interacting drugs
Peritoneal Dialysis Solutions
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