Gosset Molecular Classification
Cell, Epithelial Cell
Other Names
Colonocyte, Intestinal Epithelial Cell (IEC), Colonic Epithelium
Disease Roles
Colon Epithelial Cell Overview
Colon epithelial cells are the primary cell type lining the luminal surface of the colon. They form a single layer of columnar epithelial cells, which are organized into crypts and play essential roles in nutrient absorption, barrier function, immune modulation, and maintenance of intestinal homeostasis. The colonic epithelium comprises several specialized cell types, including enterocytes, goblet cells, and enteroendocrine cells, all derived from stem cells at the base of the crypts.
Mechanism of Action
Biological Functions
Absorption
Barrier Function
Immune Modulation
Secretion
Homeostasis
Regeneration
Disease Associations
Colorectal Cancer
Inflammatory Bowel Disease (IBD)
Infection
Other Gastrointestinal Diseases
Safety Considerations
- Dysregulation can lead to cancer
- Barrier disruption can lead to inflammation and infection
Associated Biomarkers
| Biomarker |
|---|
| CD44 |
| LGR5 |
| EpCAM |