Gosset Molecular Classification
Microbial Community, Bacteria
Other Names
Colonic Microbiota, Gut Flora of the Colon, Gut Microbiome (Colon Specific)
Disease Roles
Colonic Bacteria Overview
Colonic bacteria, also known as the colonic microbiota or gut flora of the colon, are a diverse community of microorganisms—primarily bacteria—that inhabit the large intestine (colon) in humans and other animals. These bacteria are mostly anaerobic, thriving in the low-oxygen environment of the colon. They play essential roles in digestion, metabolism, immune function, and maintaining overall gut health. Key functions include fermentation of undigested carbohydrates, nutrient synthesis (e.g., vitamins), and immune modulation. Disruption or imbalance (dysbiosis) can lead to increased susceptibility to infections and various diseases.
Mechanism of Action
N/A (Complex Community - Mechanisms Vary Widely Depending on Specific Bacteria)
Biological Functions
Fermentation
Nutrient Synthesis
Immune Modulation
Digestion
Metabolism
Colonization Resistance
Disease Associations
Inflammatory Bowel Disease (IBD)
Infection (e.g., Clostridioides difficile)
Obesity
Diabetes
Autoimmune Conditions
Mental Health (Potential Influence)
Ulcerative Colitis
Safety Considerations
- Dysbiosis
- Opportunistic Infections
- Potential for harmful metabolite production (e.g., hydrogen sulfide)
- Antibiotic resistance transfer
Interacting Drugs
Antibiotics
Probiotics
Prebiotics
Fecal Microbiota Transplantation (FMT)
Associated Biomarkers
| Biomarker |
|---|
| Specific bacterial species abundance/diversity |
| Short-chain fatty acid (SCFA) levels |
| Metabolomic profiles |
| Fecal calprotectin (as an indicator of inflammation indirectly related to bacterial composition) |