Gosset Molecular Classification
Tissue, Epithelium, Connective Tissue, Smooth Muscle
Disease Roles
Colonic Mucosa Overview
The colonic mucosa is the specialized inner lining of the colon, comprising an epithelial layer, lamina propria, and muscularis mucosae. It functions as a selective barrier, mediates absorption and secretion, and plays a crucial role in immune defense. It is the primary site of origin for many diseases affecting the colon, including cancer and inflammatory bowel disease.
Mechanism of Action
Varies depending on the drug. Anti-inflammatory drugs reduce inflammation; immunosuppressants suppress the immune system; biologics target specific immune mediators; chemotherapeutic agents kill cancer cells.
Biological Functions
Absorption
Secretion
Barrier function
Immune defense
Lubrication
Disease Associations
Colorectal cancer
Inflammatory bowel disease
Ulcerative colitis
Crohn's disease
Microscopic colitis
Polyp formation
Safety Considerations
- Drug-induced mucosal damage
- Increased risk of infection with immunosuppressants
- Gastrointestinal side effects (e.g., diarrhea, bleeding)
- Risk of dysplasia/cancer development in chronic inflammation
Interacting Drugs
Anti-inflammatory drugs (e.g., corticosteroids, aminosalicylates)
Immunosuppressants (e.g., azathioprine, methotrexate)
Biologics (e.g., anti-TNF agents, anti-integrins)
Chemotherapeutic agents (e.g., 5-fluorouracil, oxaliplatin)
Associated Biomarkers
| Biomarker |
|---|
| Histological features (crypt architecture, inflammation) |
| Ki67 (proliferation marker) |
| p53 (tumor suppressor gene expression) |
| Microsatellite instability (MSI) |
| Immunohistochemical markers (e.g., CD3, CD20, CD68 for immune cell populations) |