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Target intelligence / Profile preview
Colony stimulating factor–1 receptor (CSF–1R)
- Target
- CSF–1R
- Molecular classification
- Receptor tyrosine kinase, RTKIII
01
Overview
Colony stimulating factor–1 receptor (CSF–1R) is a type III receptor tyrosine kinase (RTKIII) that plays a crucial role in the survival, proliferation, and differentiation of myeloid lineage cells, including monocytes, macrophages, and osteoclasts. It is activated by its ligands, colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34), leading to downstream signaling through pathways such as PI3K/AKT, MAPK/ERK, and STAT. CSF-1R is implicated in various diseases, including adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and cancer, making it a therapeutic target for CSF–1R inhibitors aimed at depleting/reprogramming tumor-associated macrophages (TAMs) and modulating immune responses.
- Other names
- M-CSFRCD115c-FMS
02
Mechanism of action
Depletion/reprogramming of tumor-associated macrophages (TAMs); Modulation of immune responses against tumors
03
Biological functions
Myeloid cell survivalMyeloid cell proliferationMyeloid cell differentiationOsteoclast precursor survivalOsteoclast proliferationOsteoclast maturationOsteoclast fusionBone resorptionGlial cell proliferationGlial cell differentiationImmune modulation
04
Disease associations
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)CancerNeurodegenerative disease
05
Safety considerations
To be determined in clinical trials
06
Interacting drugs
CSF–1R inhibitors
07
Biomarkers
High intratumoral CSF–1R+ macrophage presence
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