Gosset Molecular Classification
Cytokine, Growth factor
Other Names
Macrophage colony-stimulating factor, M-CSF
Disease Roles
Colony Stimulating Factor 1 Overview
Colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine that plays a central role in the regulation of survival, proliferation, differentiation, and function of mononuclear phagocytes—primarily macrophages and their progenitors. It exerts its biological effects by binding to the high-affinity cell-surface tyrosine kinase receptor CSF-1R. Targeting the CSF1/CSF1R axis has become an area for therapeutic intervention, particularly in oncology settings, due to its role in modulating tumor-associated macrophages.
Mechanism of Action
Inhibition of CSF1 signaling, either by directly targeting the CSF1 ligand or the CSF1R receptor.
Biological Functions
Hematopoiesis
Regulation of mononuclear phagocyte survival
Regulation of mononuclear phagocyte proliferation
Regulation of mononuclear phagocyte differentiation
Regulation of mononuclear phagocyte function
Chemotaxis
Cell migration
Tissue repair
Homeostasis
Disease Associations
Cancer progression
Innate immunity
Inflammation
Systemic lupus erythematosus (SLE)
Arthritis
Atherosclerosis
Obesity-related inflammation
Safety Considerations
- Modulation of tumor-associated immune cells
- Potential impact on normal macrophage function
- Safety profiles are still under investigation in trials
Interacting Drugs
Emactuzumab
MCS110
PD‑0360324