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Target intelligence / Profile preview
Macrophage Colony-Stimulating Factor Receptor (CSF1R)
- Target
- CSF1R
- Molecular classification
- Receptor, Type III Tyrosine Kinase Transmembrane Receptor, Protein Tyrosine Kinase
01
Overview
CSF1R is a type III transmembrane protein tyrosine kinase receptor primarily expressed on myeloid lineage cells. Ligand binding (CSF-1 or IL-34) leads to receptor dimerization, autophosphorylation, and activation of downstream signaling pathways (PI3K/Akt, JNK, ERK1/2) regulating cell survival, proliferation, differentiation, migration and function of myeloid cells. It is implicated in diseases like ALSP, leukodystrophy, skeletal dysplasia and cancer.
- Other names
- Colony stimulating factor 1 receptorM-CSFRCD115c-FMS
02
Mechanism of action
CSF‑1 or IL‑34 binds extracellular domain; Receptor homodimerizes; Intracellular tyrosine residues phosphorylated; Activates PI3K/Akt/JNK/ERK/MAPK & other pathways; Promotes survival/proliferation/differentiation/migration
03
Biological functions
Cell survivalCell proliferationCell differentiationCell migrationActin cytoskeleton reorganizationSignal transductionImmune responseMicroglial homeostasisTissue repair
04
Disease associations
CancerAdult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)LeukodystrophySkeletal dysplasiaNeurodegenerative diseaseInflammationBone diseases
05
Safety considerations
Safety profile needs further evaluation from clinical data
06
Interacting drugs
PLX3397
07
Biomarkers
Intratumoral CSF1R+ TAMs correlate with poor prognosis
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