Colony stimulating factor 1 receptor (CSF1R)

Colony stimulating factor 1 receptor Overview

CSF1R is a cell-surface receptor essential for the survival, proliferation, differentiation, and function of mononuclear phagocytes such as macrophages and their precursors. Its activation by CSF‑1 or IL‑34 triggers intracellular signaling cascades that regulate cell growth/division, differentiation, and survival of myeloid cells via anti-apoptotic pathways. Elevated expression of CSF‑1/CSF‑1R correlates with poor prognosis in several cancers, and mutations in *CSF1R* cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a severe neurological disorder. Targeting this axis is an active area for therapeutic development.

Mechanism of Action

Small molecule inhibitors or monoclonal antibodies designed to block ligand binding or inhibit kinase activity.

Biological Functions

Safety Considerations