Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)

Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) is a multifunctional, primarily mitochondrial matrix protein that forms a homotrimeric, doughnut-shaped structure and is involved in diverse cellular processes. C1QBP inhibits complement C1 activation by binding the globular heads of C1q; it also plays a critical role in mitochondrial oxidative phosphorylation, energy metabolism, and the regulation of mitochondrial morphology and calcium uptake. Additionally, C1QBP functions as an RNA and protein chaperone in mitochondria and interacts with several viral, bacterial, and tumor-associated peptides. Dysfunction or dysregulation of C1QBP is implicated in cancer, inflammatory conditions, cardiovascular disease, and mitochondrial disorders.

Other names

C1QBPGC1QBPHABP1SF2P32C1qBPSF2AP32gC1Q-RgC1qRp32ASF/SF2-associated protein p32glycoprotein gC1qBPhyaluronan-binding protein 1mitochondrial matrix protein p32p33C1q globular domain-binding proteinsplicing factor SF2-associated protein

LyP-1: selectively binds C1QBP, leading to tumor targeting and cytotoxicity in certain cancer models. No approved drugs/mechanisms established; mainly investigational