Gosset Molecular Classification
Protein Complex, Complement component
Other Names
C1q complex
Disease Roles
Complement component 1 q subcomponent Overview
Complement component 1q (C1q) is a crucial protein complex in the classical pathway of the complement system, part of innate immunity. C1q, along with C1r and C1s, forms the C1 complex. This complex recognizes and binds to antigen-antibody complexes, leading to activation of the classical complement cascade. C1q deficiency is strongly associated with autoimmune diseases like SLE due to impaired clearance of apoptotic cells and immune complexes. It consists of three polypeptide chains A (C1QA), B (C1QB), and C (C1QC).
Mechanism of Action
N/A
Biological Functions
Innate immunity
Activation of classical complement pathway
Clearance of pathogens
Clearance of apoptotic cells
Clearance of immune complexes
Disease Associations
Autoimmunity
Systemic lupus erythematosus (SLE)
Safety Considerations
- Potential for off-target effects on other complement pathways
- Risk of inducing or exacerbating autoimmune diseases if improperly targeted