Gosset Molecular Classification
Serine protease, Enzyme
Other Names
C2, ARMD14, CO2, complement component 2
Disease Roles
Complement Component 2 Overview
Complement C2 is a key protein in the classical and lectin pathways of the complement system. It is a serine protease that participates in forming the classical pathway’s central enzyme complexes and is crucial for pathogen recognition, opsonization, and clearance. Deficiency or dysfunction of C2 can lead to increased susceptibility to infections and autoimmune diseases.
Mechanism of Action
siRNA-based inhibition, CRISPR/Cas9 gene editing, Antibody-based neutralization
Biological Functions
Immune response
Complement activation
Pathogen recognition
Opsonization
Formation of C3 convertase
Disease Associations
Immunodeficiency
Autoimmune disease
Infection
Safety Considerations
No safety concerns listed