Complement component 4 binding protein, alpha pseudogene 1 (C4BPAP1)

C4BPAP1 is a member of the regulator of complement activation (RCA) gene cluster that evolved from duplication of the C4BPA gene after the separation of rodent and primate lineages[3][5]. It is located approximately 20 kb downstream of the C4BPA gene and shares sequence homology with several exons of C4BPA. Sequence analyses show it possesses nine exon-like regions homologous to the functional gene but currently does not code for an active protein in humans—it is considered a pseudogene[3]. Historically, C4BPAP1 may once have encoded a protein with structural similarity to the C4b-binding protein alpha chain, yet it is now non-functional due to accumulated mutations and the absence of required regulatory elements[3][5]. Key points: - C4BPAP1 is not a therapeutic target, nor does it encode a receptor, transporter, enzyme, or functional protein in humans[3]. It should not be confused with the functional gene C4BPA, which plays an important role in complement regulation and is associated with immune and thrombotic diseases[1][5]. - C4BPAP1 is not associated with any drugs, biological functions, or disease mechanisms. There are no known biomarkers or safety concerns linked specifically to this pseudogene. If information about a functional protein target is needed, refer to C4BPA (complement component 4 binding protein, alpha), not C4BPAP1.

Other names

C4BPAP1C4BPAL1complement component 4 binding protein alpha pseudogene 1complement component 4-binding protein alpha-like 1