Complement-Dependent Cytotoxicity (None)

Complement-Dependent Cytotoxicity Overview

Complement-dependent cytotoxicity (CDC) is a biological mechanism by which the immune system destroys target cells, such as bacteria, virus-infected cells, or tumor cells. This process is initiated when antibodies—primarily IgG1, IgG3, and IgM—isotypes—bind to antigens on the surface of a target cell. The Fc region of these antibodies then interacts with C1q, the first component of the classical complement pathway. This triggers a cascade that leads to the assembly of the membrane attack complex (MAC), resulting in pore formation in the cell membrane and subsequent lysis or death of the target cell.

Mechanism of Action

Antibody-mediated complement activation leading to MAC formation and cell lysis

Biological Functions

Safety Considerations

Interacting Drugs