Complement Membrane Attack Complex (MAC)

The complement membrane attack complex (MAC) is a multi-protein structure formed during the activation of the complement system. MAC assembles on the surface of target cells, forming transmembrane pores that disrupt cellular integrity, leading to cell lysis and death. While primarily known for its cytolytic function, sublytic MAC deposition can also trigger intracellular signaling pathways and induce proinflammatory responses. It represents a therapeutic target in various diseases, particularly those involving excessive complement activation or uncontrolled inflammation. Inhibiting MAC formation or function can be a strategy to mitigate tissue damage and disease progression.

Other names

Membrane Attack ComplexTerminal Complement ComplexTCC

Pore formation leading to cell lysis