Gosset Molecular Classification
Multi-protein complex, Pore-forming complex, Complement system component
Other Names
Terminal Complement Complex, TCC, C5b-9
Disease Roles
Complement Protein C5b-C9 Membrane Attack Complex Overview
The complement protein C5b-C9 membrane attack complex (MAC) is a multi-protein structure formed during activation of the complement system. The MAC forms transmembrane pores in target cell membranes, leading to cell lysis and death. It is composed of C5b, C6, C7, C8, and multiple copies of C9. Excessive or misdirected activation contributes to tissue damage in autoimmune diseases. Regulation by clusterin/vitronectin prevents uncontrolled damage.
Mechanism of Action
Pore formation in target cell membranes, leading to cell lysis
Biological Functions
Cytolysis
Immune defense
Pore formation
Cell death
Inflammation
Complement activation
Disease Associations
Autoimmune diseases
Lupus nephritis
Kidney pathologies
Inflammation
Tissue injury
Safety Considerations
- Uncontrolled complement activation leading to tissue damage
- Off-target effects on host cells
Associated Biomarkers
| Biomarker |
|---|
| sC5b-9 (soluble MAC) |